eQTL mapping for innate immunity
نویسندگان
چکیده
منابع مشابه
MAPping innate immunity.
T he capacity to mount an immune response that eliminates infection of a host by a microbial pathogen is critical for species survival and propagation. Mammals have developed complex immune systems that integrate innate responses, such as phagocytosis and the production of antimicrobial peptides after Toll-like receptor activation, along with adaptive responses, such as antibody production and ...
متن کاملTitle: a Model Selection Approach for Expression Quantitative Trait Loci (eqtl) Mapping Running Title: Model Selection for Eqtl Mapping
Identifying the genetic basis of complex traits remains an important and challenging problem with the potential to impact a broad range of biological endeavors. A number of statistical methods are available for mapping quantitative trait loci (QTL), but their application to high throughput phenotypes has been limited as most require user input and interaction. Recently, methods have been develo...
متن کاملInnate immunity
From the discovery of antibodies in the late nineteenth century until very recently, the focus of most research in immunology has been the so-called adaptive immune response. Adaptive immune responses are highly specific for a given microorganism and it is the T and B lymphocytes of the adaptive immune response, and the antibodies produced by the B lymphocytes, that are responsible for lasting ...
متن کاملInnate immunity.
Recent years have witnessed an explosion of interest in the innate immune system. Questions about how the innate immune system senses infection and empowers a protective immune response are being answered at the molecular level. These basic science discoveries are being translated into a more complete understanding of the central role innate immunity plays in the pathogenesis of many human infe...
متن کاملeQTL Mapping Using RNA-seq Data.
As RNA-seq is replacing gene expression microarrays to assess genome-wide transcription abundance, gene expression Quantitative Trait Locus (eQTL) studies using RNA-seq have emerged. RNA-seq delivers two novel features that are important for eQTL studies. First, it provides information on allele-specific expression (ASE), which is not available from gene expression microarrays. Second, it gener...
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ژورنال
عنوان ژورنال: Nature Genetics
سال: 2014
ISSN: 1061-4036,1546-1718
DOI: 10.1038/ng.2945